Pharmacological properties: anti-inflammatory and antiallergic, antibacterial, antifungal.
Betamethasone has anti-inflammatory and antiallergic and antipruritic effect. Hinders the accumulation of leukocytes, release of lysosomal enzymes and proinflammatory mediators in inflammation, inhibits phagocytosis, reduces vascular tissue permeability, prevents the formation of inflammatory edema.
Clotrimazole has antifungal action as a result of violations of synthesis of ergosterol, an integral part of the cell membrane of fungi. Active against: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare).
Gentamicin - broad spectrum antibiotic of aminoglycoside, has a bactericidal action against Gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp., Staphylococcus aureus.
For cutaneous use of the drug in dosage transdermal absorption of active substances in the blood is very low. The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which can lead to increased risk of systemic side effects.
INDICATIONS: dermatitis, complicated by secondary bacterial and / or fungal infection, epidermofitiya stop, dermatomycoses caused by sensitive to clotrimazole mushrooms.
APPLICATION: cream applied topically. Dose was set individually, because it depends on the area of the affected area. The cream should be applied to the affected skin with a thin layer 2 times a day (morning and evening), gently rubbing the skin, after reaching a clinical improvement rate of the drug can be reduced to 1 times per day. To increase the effectiveness of treatment can be applied occlusive dressings. Duration Treatment is determined by the abolishment of the inflammatory process and negative data of bacterial and / or mycological analysis, end-of itching, peeling skin, duration of treatment depends on the type and severity of the disease, the effectiveness and sensitivity to therapy, determined by a physician and is usually less than 2-4 weeks ; between repeated courses must wait at least 20 days. The course of treatment in children and patients with damage to a person shall not exceed 5 days.
Children aged 7-16 years, a drug prescribed only strictly according to strict indications and under the supervision of a doctor. Children are not encouraged to use the drug in large areas of the body, as well as the use of occlusive dressings.
CONTRAINDICATIONS: primary viral skin infections, tuberculosis, skin, cutaneous manifestations of syphilis, skin reactions after vaccination, acne, increased sensitivity to the drug's components, the age of 7 years, during pregnancy and lactation.
SIDE EFFECTS: The drug is generally well tolerated, with proper application of the side effects are rare, but may be burning sensation, irritation, hyperemia, erythema, itching, dryness, peeling, pigmentation disorders, maceration, skin atrophy, striae, hypertrichosis, folliculitis, miliaria, urticaria , acne, perioral dermatitis. In the application of occlusive dressings is most likely the appearance of maceration of the skin, striae and miliaria. Prolonged use of possible systemic side effects (depression of function of the adrenal cortex).
Cautions: should not be allowed contact with the drug in the eyes, on broken skin and open wound sites. Do not put the cream on the skin around the eyes. In order to improve the effectiveness of therapy may use occlusive dressings, but please keep in mind that there is increased transdermal absorption of betamethasone and gentamicin, leading to an increased risk of systemic side effects. Systemic absorption of betamethasone increases when applying the cream for a long time, when applied to large body surface, as well as children.
When a resistant bacterial or fungal microflora should stop using the product and assign the appropriate therapy. Perhaps the development of cross-resistance to aminoglycoside antibiotics.
INTERACTION: data on drug interactions with other drugs in its local application are not available.
OVERDOSE: Excessive and prolonged use of the drug over a large surface of the skin may lead to the manifestation of systemic effects inherent in the SCS, in particular the oppression of the hypothalamic-pituitary-adrenal system to the development of secondary adrenal insufficiency and Cushing's symptoms (weight gain, edema formation, AH Glycosuria, hypokalaemia), including Itsenko syndrome - Cushing's (especially children). Children in overdose than it is possible to decrease the creation of growth hormone, increased intracranial pressure.
Treatment: symptomatic therapy, if necessary, carry out correction of electrolyte balance. It is recommended that the phasing out of the drug.
Storage conditions: at a temperature of 15-25 ° C. Do not freeze.
Betamethasone has anti-inflammatory and antiallergic and antipruritic effect. Hinders the accumulation of leukocytes, release of lysosomal enzymes and proinflammatory mediators in inflammation, inhibits phagocytosis, reduces vascular tissue permeability, prevents the formation of inflammatory edema.
Clotrimazole has antifungal action as a result of violations of synthesis of ergosterol, an integral part of the cell membrane of fungi. Active against: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare).
Gentamicin - broad spectrum antibiotic of aminoglycoside, has a bactericidal action against Gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp., Staphylococcus aureus.
For cutaneous use of the drug in dosage transdermal absorption of active substances in the blood is very low. The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which can lead to increased risk of systemic side effects.
INDICATIONS: dermatitis, complicated by secondary bacterial and / or fungal infection, epidermofitiya stop, dermatomycoses caused by sensitive to clotrimazole mushrooms.
APPLICATION: cream applied topically. Dose was set individually, because it depends on the area of the affected area. The cream should be applied to the affected skin with a thin layer 2 times a day (morning and evening), gently rubbing the skin, after reaching a clinical improvement rate of the drug can be reduced to 1 times per day. To increase the effectiveness of treatment can be applied occlusive dressings. Duration Treatment is determined by the abolishment of the inflammatory process and negative data of bacterial and / or mycological analysis, end-of itching, peeling skin, duration of treatment depends on the type and severity of the disease, the effectiveness and sensitivity to therapy, determined by a physician and is usually less than 2-4 weeks ; between repeated courses must wait at least 20 days. The course of treatment in children and patients with damage to a person shall not exceed 5 days.
Children aged 7-16 years, a drug prescribed only strictly according to strict indications and under the supervision of a doctor. Children are not encouraged to use the drug in large areas of the body, as well as the use of occlusive dressings.
CONTRAINDICATIONS: primary viral skin infections, tuberculosis, skin, cutaneous manifestations of syphilis, skin reactions after vaccination, acne, increased sensitivity to the drug's components, the age of 7 years, during pregnancy and lactation.
SIDE EFFECTS: The drug is generally well tolerated, with proper application of the side effects are rare, but may be burning sensation, irritation, hyperemia, erythema, itching, dryness, peeling, pigmentation disorders, maceration, skin atrophy, striae, hypertrichosis, folliculitis, miliaria, urticaria , acne, perioral dermatitis. In the application of occlusive dressings is most likely the appearance of maceration of the skin, striae and miliaria. Prolonged use of possible systemic side effects (depression of function of the adrenal cortex).
Cautions: should not be allowed contact with the drug in the eyes, on broken skin and open wound sites. Do not put the cream on the skin around the eyes. In order to improve the effectiveness of therapy may use occlusive dressings, but please keep in mind that there is increased transdermal absorption of betamethasone and gentamicin, leading to an increased risk of systemic side effects. Systemic absorption of betamethasone increases when applying the cream for a long time, when applied to large body surface, as well as children.
When a resistant bacterial or fungal microflora should stop using the product and assign the appropriate therapy. Perhaps the development of cross-resistance to aminoglycoside antibiotics.
INTERACTION: data on drug interactions with other drugs in its local application are not available.
OVERDOSE: Excessive and prolonged use of the drug over a large surface of the skin may lead to the manifestation of systemic effects inherent in the SCS, in particular the oppression of the hypothalamic-pituitary-adrenal system to the development of secondary adrenal insufficiency and Cushing's symptoms (weight gain, edema formation, AH Glycosuria, hypokalaemia), including Itsenko syndrome - Cushing's (especially children). Children in overdose than it is possible to decrease the creation of growth hormone, increased intracranial pressure.
Treatment: symptomatic therapy, if necessary, carry out correction of electrolyte balance. It is recommended that the phasing out of the drug.
Storage conditions: at a temperature of 15-25 ° C. Do not freeze.
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