Pharmacological properties: Dolar - combination drug, which has expressed anti-inflammatory, analgesic and antipyretic effect. Pharmacological activity of the drug due to the properties of diclofenac and paracetamol, comprising Dolar. Diclofenac sodium has a marked anti-inflammatory and analgesic, and mild antipyretic effect. Paracetamol has a pronounced analgesic, antipyretic and anti-negligible effect. The mechanism of action is associated with inhibition of prostaglandin synthesis.
When you receive diclofenac sodium inside the active substance is rapidly absorbed into the blood, the maximum plasma concentration is achieved in 1-2 hours a meal slows absorption, but does not affect its level. The drug is 99% associated with blood plasma proteins, well into the tissue and synovial fluid, where its concentration may exceed those in blood plasma. Half life of plasma is 1-2 h of synovial fluid - 3-6 pm Diclofenac sodium is metabolized in the liver, about 35% of drugs excreted in the urine as metabolites and approximately 1% - unchanged, about 35% - with feces. When administered paracetamol is well absorbed. The maximum concentration in blood is achieved within 30 min after administration and lasted approximately 1 h. About 25% of the drug binds to plasma proteins of blood, half-life - 1,5-2 pm By hepatic metabolism and is transformed into glucuronide sulfates. The concentration of the drug in the urine than in blood plasma.
INDICATIONS: headache, toothache, neuralgia, lumbago, sciatica, lumbago, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, diseases of the joints and spine, soft tissue, febrile conditions, acute musculo-skeletal pain, tendinitis, bursitis, post-operative pain, dysmenorrhea.
APPLICATION: depend on the nature and course of disease, tolerability and efficacy of the drug.
Adults and children over 6 years - 1 tablet 2-3 times daily after meals. The course of treatment is 5-7 days, depending on the dynamics of symptoms. Maximum daily dose for adults is 3 tablets a day.
In appointing Dolar children aged 6-12 years should take into account that the daily dose of diclofenac should not exceed 0,5-2 mg / kg body weight; dose divided by 2-3 reception. The maximum daily dose for children is calculated by diclofenac at 3 mg / kg body weight.
CONTRAINDICATIONS:
-Peptic ulcers of the stomach or duodenum exacerbation;
- Diseases of the liver or kidneys;
- Increased sensitivity to the drug's components;
- AD;
- Urticaria;
- Acute ritnit and other allergic reactions associated with NSAID intake;
- Hemodyscrasia of unknown origin;
- During pregnancy and lactation;
- The age of 6 years.
SIDE EFFECTS:
On the part of the digestive tract: nausea, anorexia, pain in the epigastric region, flatulence, constipation, diarrhea. In some cases, especially with frequent and prolonged use of the drug, possibly erosive-ulcerative lesion of digestive organs with signs of gastrointestinal bleeding (black feces).
From the side of the central nervous system: rarely - headache, depression, drowsiness.
From the urinary system: rarely - hematuria, proteinuria, nephrotic syndrome, acute renal failure.
On the part of the hemopoietic system: very rarely - thrombocytopenia, anemia (due to hidden bleeding from the gastrointestinal tract).
Allergic reactions (especially in asthmatic patients): skin rash, bronchospasm, pruritus, erythema.
Cautions: during application Dolar should be closely monitored and regular medical examination of patients with diseases of the digestive tract in history (especially with ulcers of the stomach or intestine); patients with ulcerative colitis or Crohn's disease, patients with impaired liver and kidney function. At the time of dollars, like other NSAIDs, may increase the activity of liver enzymes, and therefore should regularly conduct a study of liver function. If you have symptoms, gastrointestinal tract, liver, or in case of any other side effects (eosinophilia, rash, etc.), the medication should be abolished.
In connection with the role of prostaglandins in maintaining renal blood flow should be very careful when appointing the drug to patients with renal insufficiency.
With the emergence of changes in the urinary system (hematuria, proteinuria, nephrotic syndrome) discontinuing treatment usually leads to recovery of renal function. Prolonged use of dollars, like other NSAIDs, shows a picture of systematic monitoring of peripheral blood. Dolar may temporarily inhibit platelet aggregation. Therefore, patients with disorders of hemostasis requires careful monitoring of laboratory parameters.
Effects on ability to drive vehicles and working with potentially dangerous machinery. Patients who feel during the reception Dolar dizziness or blurred vision, drive vehicles and operate potentially dangerous machinery is not recommended.
INTERACTION: while receiving Dolar reduces the effect of furosemide and antihypertensive drugs, increases the concentration of digoxin in the blood plasma.
Combine techniques with potassium-sparing diuretics may lead to the development of hyperkalemia. With simultaneous use of other NSAIDs, or SCS increased risk of gastrointestinal bleeding. Undesirable to the combined use of Dolar with methotrexate and cyclosporine.
OVERDOSE:
Symptoms: hypotension, respiratory depression, convulsions, kidney failure, violations of the gastrointestinal tract.
Treatment: symptomatic therapy, forced diuresis, dialysis or blood transfusions are ineffective because the active ingredient is largely associated with plasma proteins.
Storage: Store in a dry place protected from light at 25 ° C.
When you receive diclofenac sodium inside the active substance is rapidly absorbed into the blood, the maximum plasma concentration is achieved in 1-2 hours a meal slows absorption, but does not affect its level. The drug is 99% associated with blood plasma proteins, well into the tissue and synovial fluid, where its concentration may exceed those in blood plasma. Half life of plasma is 1-2 h of synovial fluid - 3-6 pm Diclofenac sodium is metabolized in the liver, about 35% of drugs excreted in the urine as metabolites and approximately 1% - unchanged, about 35% - with feces. When administered paracetamol is well absorbed. The maximum concentration in blood is achieved within 30 min after administration and lasted approximately 1 h. About 25% of the drug binds to plasma proteins of blood, half-life - 1,5-2 pm By hepatic metabolism and is transformed into glucuronide sulfates. The concentration of the drug in the urine than in blood plasma.
INDICATIONS: headache, toothache, neuralgia, lumbago, sciatica, lumbago, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, diseases of the joints and spine, soft tissue, febrile conditions, acute musculo-skeletal pain, tendinitis, bursitis, post-operative pain, dysmenorrhea.
APPLICATION: depend on the nature and course of disease, tolerability and efficacy of the drug.
Adults and children over 6 years - 1 tablet 2-3 times daily after meals. The course of treatment is 5-7 days, depending on the dynamics of symptoms. Maximum daily dose for adults is 3 tablets a day.
In appointing Dolar children aged 6-12 years should take into account that the daily dose of diclofenac should not exceed 0,5-2 mg / kg body weight; dose divided by 2-3 reception. The maximum daily dose for children is calculated by diclofenac at 3 mg / kg body weight.
CONTRAINDICATIONS:
-Peptic ulcers of the stomach or duodenum exacerbation;
- Diseases of the liver or kidneys;
- Increased sensitivity to the drug's components;
- AD;
- Urticaria;
- Acute ritnit and other allergic reactions associated with NSAID intake;
- Hemodyscrasia of unknown origin;
- During pregnancy and lactation;
- The age of 6 years.
SIDE EFFECTS:
On the part of the digestive tract: nausea, anorexia, pain in the epigastric region, flatulence, constipation, diarrhea. In some cases, especially with frequent and prolonged use of the drug, possibly erosive-ulcerative lesion of digestive organs with signs of gastrointestinal bleeding (black feces).
From the side of the central nervous system: rarely - headache, depression, drowsiness.
From the urinary system: rarely - hematuria, proteinuria, nephrotic syndrome, acute renal failure.
On the part of the hemopoietic system: very rarely - thrombocytopenia, anemia (due to hidden bleeding from the gastrointestinal tract).
Allergic reactions (especially in asthmatic patients): skin rash, bronchospasm, pruritus, erythema.
Cautions: during application Dolar should be closely monitored and regular medical examination of patients with diseases of the digestive tract in history (especially with ulcers of the stomach or intestine); patients with ulcerative colitis or Crohn's disease, patients with impaired liver and kidney function. At the time of dollars, like other NSAIDs, may increase the activity of liver enzymes, and therefore should regularly conduct a study of liver function. If you have symptoms, gastrointestinal tract, liver, or in case of any other side effects (eosinophilia, rash, etc.), the medication should be abolished.
In connection with the role of prostaglandins in maintaining renal blood flow should be very careful when appointing the drug to patients with renal insufficiency.
With the emergence of changes in the urinary system (hematuria, proteinuria, nephrotic syndrome) discontinuing treatment usually leads to recovery of renal function. Prolonged use of dollars, like other NSAIDs, shows a picture of systematic monitoring of peripheral blood. Dolar may temporarily inhibit platelet aggregation. Therefore, patients with disorders of hemostasis requires careful monitoring of laboratory parameters.
Effects on ability to drive vehicles and working with potentially dangerous machinery. Patients who feel during the reception Dolar dizziness or blurred vision, drive vehicles and operate potentially dangerous machinery is not recommended.
INTERACTION: while receiving Dolar reduces the effect of furosemide and antihypertensive drugs, increases the concentration of digoxin in the blood plasma.
Combine techniques with potassium-sparing diuretics may lead to the development of hyperkalemia. With simultaneous use of other NSAIDs, or SCS increased risk of gastrointestinal bleeding. Undesirable to the combined use of Dolar with methotrexate and cyclosporine.
OVERDOSE:
Symptoms: hypotension, respiratory depression, convulsions, kidney failure, violations of the gastrointestinal tract.
Treatment: symptomatic therapy, forced diuresis, dialysis or blood transfusions are ineffective because the active ingredient is largely associated with plasma proteins.
Storage: Store in a dry place protected from light at 25 ° C.
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